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                当前位置: 首页 » 食品资讯 » 外讯导读 » 欧盟评估一种β-半乳糖苷酶的安全性

                欧盟评估一种β-半乳糖苷酶的安全性

                放大字体  缩小字体 时间:2022-07-05 11:05 来源:食品伙伴网 作者: 泽夕   
                核心提示:2022年7月4日,欧盟食品安全局就一种β-半乳糖苷酶(β-galactosidase)的安全性评价发布意见。
                   食品伙伴网讯  2022年7月4日,欧盟食品安全局就一种β-半乳糖苷酶(β-galactosidase)的安全性评价发布意见。
                 
                  据了解,这种食品酶是由转基因地衣芽孢杆菌菌株NZYM-BT生产的,旨在用于牛】奶加工中乳糖的水解。
                 
                  经过评估,专战斗力家小组认为,在预期的使用▃条件下,不能排除饮食暴露引起过敏和诱发『反应的风险,尤其是对半乳糖苷酶或悬铃木花粉的匹配过敏原敏感的个体。根据所提供的数∑ 据,小组得出结论,该食品酶在预期的使用条件下不█会引起安全隐患。部分原文报道如下:
                 
                  The food enzyme β-galactosidase (β-d-galactoside galactohydrolase; EC 3.2.1.23) is produced with the genetically modified Bacillus licheniformis strain NZYM-BT by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The production strain has been shown to qualify for the qualified presumption of safety (QPS) status. The food enzyme was considered free from viable cells of the production organism and its DNA. It is intended to be used in milk processing for the hydrolysis of lactose. based on the assumption that all selected milk and milk products are enzymatically treated, dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.34 mg TOS/kg body weight (bw) per day in European populations. Toxicological data were reported and were considered as supporting evidence of the safety of the food enzyme. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 672 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure above 1,950. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and one match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, especially in individuals sensitised to galactosidase or to the matching allergen of pollen from Platanus. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
                 
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                日期:2022-07-05
                 
                 
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