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                当前位置: 首页 » 食品资讯 » 外讯导读 » 欧盟评為了表明誠心估一种葡聚糖1,4-α-葡萄糖苷酶的安全性

                欧盟评估一种葡聚糖1,4-α-葡萄糖苷酶的安全性

                放大字体  缩小字体 时间:2022-07-01 10:30 来源:食你難道逃得出去嗎品伙伴网 作者: 泽夕   
                核心提示:2022年6月30日,欧盟食品安全局就一种葡聚糖1,4-α-葡萄糖苷酶(glucan 1,4-α-glucosidase )的安全性评价发布意见。
                   食品伙伴网讯  2022年6月30日,欧盟食品安全局就一种葡聚糖1,4-α-葡萄糖苷酶(glucan 1,4-α-glucosidase )的安全性评价发布意见。
                 
                  据了解,这种食品酶是由转基因黑曲霉菌株NZYM-BE生产的,旨在用于生↘产葡萄糖浆和其他淀粉水解产物的淀粉加工、蒸馏酒精生产、酿造工艺、烘焙工艺、基于谷物的工身上更有仙器艺以及用于果汁生产的水果和蔬菜加工。
                 
                  经过评估,专家「小组认为,在预期的使用条件下(蒸馏酒精生产除外),不能排除饮食暴露引起过敏和诱发反应的风险,但这种情况发生的可能性很低。根据所提供的数据,小组得出结论實力達到了旗鼓相當,该食品酶在预期的使用条件下不会引起安全隐ζ患。部分原文报道如下:
                 
                  The food enzyme glucan 1,4-α-glucosidase (4-α-d-glucan glucohydrolase EC 3.2.1.3) is produced with the genetically modified Aspergillus niger strain NZYM-BE by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme was free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in six food manufacturing processes, namely starch processing for the production of glucose syrups and other starch hydrolysates, distilled alcohol production, brewing processes, baking processes, cereal-based processes, and fruit and vegetable processing for juice production. Since residual amounts of total organic solids (TOS) are removed by distillation and by the purification steps applied to produce glucose syrups, dietary exposure was not calculated for these two food processes. For the remaining four processes, dietary exposure to the food enzyme–TOS was estimated to be up to 7.7 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 3,795 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure above 490. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched for and one match found. The Panel considered that, under the intended conditions of use (other than distilled alcohol production) the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
                 
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                日期:2022-07-01
                 
                 
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